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Reactions in Nitroimidazole Triggered by Low‐Energy (0–2 eV) Electrons: Methylation at N1‐H Completely Blocks Reactivity

Identifieur interne : 003D33 ( Main/Exploration ); précédent : 003D32; suivant : 003D34

Reactions in Nitroimidazole Triggered by Low‐Energy (0–2 eV) Electrons: Methylation at N1‐H Completely Blocks Reactivity

Auteurs : Katrin Tanzer [Autriche] ; Linda Feketeová [Australie, France, Autriche] ; Benjamin Puschnigg [Autriche] ; Paul Scheier [Autriche] ; Eugen Illenberger [Allemagne] ; Stephan Denifl [Autriche]

Source :

Angewandte Chemie International Edition [ 1433-7851 ] ; 2014-11-03.

RBID : ISTEX:2BB3B5E6A6AC40EA05596E225964CCE308A7B374

Abstract

Low‐energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4‐nitroimidazole (4NI) by dissociative electron attachment (DEA). The reactions include simple bond cleavages but also complex reactions involving multiple bond cleavages and formation of new molecules. Both simple and complex reactions are associated with pronounced sharp features in the anionic yields, which are interpreted as vibrational Feshbach resonances acting as effective doorways for DEA. The remarkably rich chemistry of 4NI is completely blocked in 1‐methyl‐4‐nitroimidazole (Me4NI), that is, upon methylation of 4NI at the N1 site. These remarkable results have also implications for the development of nitroimidazole based radiosensitizers in tumor radiation therapy.

Url:

https://api.istex.fr/document/2BB3B5E6A6AC40EA05596E225964CCE308A7B374/fulltext/pdf

DOI: 10.1002/anie.201407452

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Low‐energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4‐nitroimidazole (4NI) by dissociative electron attachment (DEA). The reactions include simple bond cleavages but also complex reactions involving multiple bond cleavages and formation of new molecules. Both simple and complex reactions are associated with pronounced sharp features in the anionic yields, which are interpreted as vibrational Feshbach resonances acting as effective doorways for DEA. The remarkably rich chemistry of 4NI is completely blocked in 1‐methyl‐4‐nitroimidazole (Me4NI), that is, upon methylation of 4NI at the N1 site. These remarkable results have also implications for the development of nitroimidazole based radiosensitizers in tumor radiation therapy.</div>
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Reactions in Nitroimidazole Triggered by Low‐Energy (0–2 eV) Electrons: Methylation at N1‐H Completely Blocks Reactivity

Reactions in Nitroimidazole Triggered by Low‐Energy (0–2 eV) Electrons: Methylation at N1‐H Completely Blocks Reactivity

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Abstract

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